We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: Piperidine-1,4-dicarboxylic acid mono t-butyl ester Order number: RT-PE-005 CAS: 84358-13-4 Purity: >=95% Appearance: solid MF: C11H19NO4 MW: 229.276 MP: 149 oC Description: This is a Boc-protected unnatural amino acid. |
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Product Name: Droxidopa Order number: RT-R04-029 CAS: 23651-95-8 Purity: >=95% Appearance: solid MF: C9H11NO5 MW: 213.189 MP: 225 oC Description: This compound can be a useful chiral starting material. Biologically, it is a substrate of dopodehydroxylase to convert to norepinephrine within sympathetic terminals. |
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Product Name: Methyl-(2s,4s)-4-fluoro-2-prolinate Order number: RT-R06-362 CAS: 58281-79-1 Purity: >=95% Appearance: solid MF: C6H11ClFNO2 MW: 183.607 MP: n.a. oC Description: The fluorine with strong inductive effect can enforce a particular ring pucker and accelerate cis/trans prolyl peptide bond isomerization, thereby providing conformational stability for peptides and p |