Pharmaceuticals are useful tools for mechanism of action studies in many ways. Besides being enzyme inhibitors, receptor agonists or antagonists, channel blockers, neurotransmitters themselves, they are used to compare and define other emerging compounds for their prospective applications.
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Product Name: Docetaxel Order number: 100245 CAS: 114977-28-5 Purity: >=95% Appearance: solid MF: C43H53NO14 MW: 807.89 MP: 232 (M.I.) oC Description: This inhibitor of microtubular deploymerization also interacts with bcl-2/bcl-xL gene expression. |
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Product Name: Gefitinib Order number: 100356 CAS: 184475-35-2 Purity: >=95% Appearance: solid MF: C22H24ClFN4O3 MW: 446.907 MP: 119-120(M.I.) oC Description: This EGFR inhibitor inhibits autophosphorylation and downstream singaling pathways, leading induction of apoptosis. |
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Product Name: Methotrexate Order number: 100465 CAS: 59-05-2 Purity: >=95% Appearance: solid MF: C20H22N8O5 MW: 454.447 MP: 185-204 (M.I.) oC Description: This folate antagonist inhibits DHFR and interferes with DNA synthesis, repair, and cellular replication. |
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Product Name: Etoricoxib Order number: 100556 CAS: 202409-33-4 Purity: >=95% Appearance: solid MF: C18H15ClN2O2S MW: 358.84 MP: 127-128 (M.I.) oC Description: This compound inhibits cyclo-oxygenase-2 (COX-2) enzyme. |
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Product Name: Vandetanib Order number: 100787 CAS: 443913-73-3 Purity: >=95% Appearance: solid MF: C22H24BrFN4O2 MW: 475.362 MP: 235 oC Description: This compound inhibits VEGFR-2 and epidermal growth factor receptor (EGFR) tyrosine kinase activity. |
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Product Name: N-(3-Benzoylamido-6-methylphenyl)-4-(3-pyridyl)-2-pyrimidine amine (CGP-53716) Order number: RT-BS-027 CAS: 152459-94-4 Purity: >=95% Appearance: solid MF: C23H19N5O MW: 381.439 MP: n.a. oC Description: This substance inhibits protein-tyrosine kinase and exhibits selectivity for the PDGF receptor in vitro and in the cell. |