Amino Acids, Nucleosides and Nucleotides

Amino Acids

We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.

Nucleosides and Nucleoside Phosphoramidites

We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.

Nucleotides

dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.

Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.

  • Amino Acids for Stapled Peptides
  • 2-Methylated Amino Acids
  • Peptide Labeling
  • Other Unnatural Amino Acids
  • Nucleosides
  • HNA Precursors
  • Morpholino Nucleosides
  • Nucleoside Phosphoramidites and Nucleotides
  • Structure Details
    Product Name: 2-Amino-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one
    Order number: 201164
    CAS: 7355-55-7
    Purity: >=95%
    Appearance: solid
    MF: C6H6N4O
    MW: 150.1
    MP: n.a. oC

    Description:
    Deazapurine base for synthesizing nucleoside.
    Product Name: (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-2-methylhept-6-enoic acid
    Order number: 201167
    CAS: 288617-73-2
    Purity: >=95%
    Appearance: solid
    MF: C23H25NO4
    MW: 379.5
    MP: n.a. oC

    Description:
    This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction.
    Product Name: 8-Azidoadenosine
    Order number: 201183
    CAS: 4372-67-2
    Purity: >=95%
    Appearance: solid
    MF: C10H12N8O4
    MW: 308.3
    MP: n.a. oC

    Description:
    This is a nucleoside for antiviral activity and potential labeling purpose via click chemistry.
    Product Name: 2',3'-Dideoxyuridine
    Order number: 201284
    CAS: 5983--09-5
    Purity: >=95%
    Appearance: solid
    MF: C9H12N2O4
    MW: 212.2
    MP: n.a. oC

    Description:
    The dideoxyuridine nucleosides have found broad antiviral activities.
    Product Name: 2'-Azido-2'-deoxyuridine
    Order number: 201288
    CAS: 26929-65-7
    Purity: >=95%
    Appearance: solid
    MF: C9H11N5O5
    MW: 269.2
    MP: n.a. oC

    Description:
    This is a nucleoside for antiviral activity and potential labeling purpose via click chemistry.
    Product Name: 2-Thiothymidine
    Order number: 201294
    CAS: 28585-51-5
    Purity: >=95%
    Appearance: solid
    MF: C10H14N2O4S
    MW: 258.3
    MP: n.a. oC

    Description:
    Thiothymidines have been used for anti-herpesvirus studies.