Pharmaceuticals are useful tools for mechanism of action studies in many ways. Besides being enzyme inhibitors, receptor agonists or antagonists, channel blockers, neurotransmitters themselves, they are used to compare and define other emerging compounds for their prospective applications.
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Product Name: MS275 (entinostat) Order number: RT-R07-422 CAS: 209783-80-2 Purity: >=95% Appearance: solid MF: C21H20N4O3 MW: 376.416 MP: n.a. oC Description: This substance inhibits HDAC enzymes including the production and acetylation of Runx2, ALP, DMP-1, and DSPP. |
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Product Name: Flavopiridol Order number: RT-R09-149 CAS: 146426-40-6 Purity: >=95% Appearance: MF: C21H20ClNO5 MW: 401.843 MP: 169.5 oC (HCl, M.I.) oC Description: This substance inhibits cyclin-dependent kinases (CDKs) by competing with adenosine triphosphate (ATP) for the active site of each kinase. |
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Product Name: Lenalidomide Order number: RT-R09-153 CAS: 191732-72-6 Purity: >=95% Appearance: solid MF: C13H13N3O3 MW: 259.265 MP: n.a. oC Description: This substance modulates substrate specificity of the CRL4CRBN E3 ubiquitin ligase, causing these transcriptional factors to break down. |
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Product Name: Docetaxel trihydrate Order number: RT-R09-154 CAS: 148408-66-6 Purity: >=95% Appearance: solid MF: C43H59NO17 MW: 861.935 MP: 232 (M.I.) oC Description: This inhibitor of microtubular deploymerization also interacts with bcl-2/bcl-xL gene expression. |
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Product Name: D,L-Dihydroorotic acid Order number: RT-R1-155 CAS: 6202-10--4 Purity: >=95% Appearance: solid MF: C5H6N2O4 MW: 158.113 MP: n.a. oC Description: This is a racemic mixture of L and D isomers of dihydroorotic acid. |
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Product Name: L-Dihydroorotic acid Order number: RT-R1-168 CAS: 5988-19-2 Purity: >=95% Appearance: solid MF: C5H6N2O4 MW: 158.113 MP: 254 oC Description: L-Dihydroorotic acid exists in living organisms. It is implicated in the metabolic disorder called the beta-ureidopropionase deficiency pathway. |