Research Pharmaceuticals and Intermediates

Pharmaceuticals are useful tools for mechanism of action studies in many ways. Besides being enzyme inhibitors, receptor agonists or antagonists, channel blockers, neurotransmitters themselves, they are used to compare and define other emerging compounds for their prospective applications.

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Structure	Details
	Product Name: 4-tert-Butoxycarbonylaminopyridine Order number: RT-R2-093 CAS: 98400-69-2 Purity: >=95% Appearance: solid MF: C10H14N2O2 MW: 194.234 MP: 150 oC Description: 4-AP known to block potassium ion channel and increase the release of acetylcholine at the neuromuscular junction and in the central nervous system. Login to check availability and price information.
	Product Name: 6-Hydroxy-N-methyl-N-(2-(4-phenylphenyl)ethyl)-1,2,3,4-tetrahydro-1-naphthalene methanamine (A 60586) Order number: RT-R2-188 CAS: 146667-75-6 Purity: >=95% Appearance: solid MF: C26H29NO MW: 371.524 MP: n.a. oC Description: This substance inhibits ergosterol, a 5,7-diene oxysterol, which is the most abundant sterol in fungal cell membranes, where it regulates permeability and fluidity. Login to check availability and price information.
	Product Name: 4,5-Dihydro-1-phenyl-5-methoxy-carbonylmethylene-8-chloro-2,5-benzodiazepin-4-one Order number: RT-S1-420 CAS: n.a. Purity: >=95% Appearance: solid MF: C18H15ClN2O3 MW: 342.779 MP: n.a. oC Description: This product may be used for medical research on CNS related conditions. Login to check availability and price information.
	Product Name: 7-ethyl-10-hydroxycamptothecin (SN-38), 99 Order number: 50P114089 CAS: 86639-52-3 Purity: >=95% Appearance: solid MF: C22H20N2O5 MW: 392.411 MP: n.a. oC Description: This compound is a potent polymerase I inhibitor, causing double-strand DNA to break. Login to check availability and price information.
	Product Name: (S)-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione Order number: 50P550528 CAS: 19685-09-7 Purity: >=95% Appearance: solid MF: C20H16N2O5 MW: 364.357 MP: n.a. oC Description: This compound is a potent polymerase I inhibitor, causing double-strand DNA to break. Login to check availability and price information.
	Product Name: Irinotecan hydrochloride trihydrate, 98 Order number: 50P987783 CAS: 136572-09-3 Purity: >=95% Appearance: solid MF: C33H45ClN4O9 MW: 677.192 MP: 250-256 (dec.) oC Description: This compound is an analog of camptothecin. Irinotecan competes for binding to DNA strand to prevent formation of topoisomerase I-DNA complex, thereby causing double-strand DNA breakage. Login to check availability and price information.

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