Research Pharmaceuticals and Intermediates

Pharmaceuticals are useful tools for mechanism of action studies in many ways. Besides being enzyme inhibitors, receptor agonists or antagonists, channel blockers, neurotransmitters themselves, they are used to compare and define other emerging compounds for their prospective applications.

Group 2

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Structure	Details
	Product Name: 5-Methoxyindole-3-carboxaldehyde Order number: RT-GA-009 CAS: 10601-19-1 Purity: >=95% Appearance: solid MF: C10H9NO2 MW: 175.187 MP: 181 oC Description: Indolecarboxaldehyde has been used to make Aplicyanin analogs (pyrimidone ring system) for anticancer evaluation. Login to check availability and price information.
	Product Name: MS275 (entinostat) Order number: RT-R07-422 CAS: 209783-80-2 Purity: >=95% Appearance: solid MF: C21H20N4O3 MW: 376.416 MP: n.a. oC Description: This substance inhibits HDAC enzymes including the production and acetylation of Runx2, ALP, DMP-1, and DSPP. Login to check availability and price information.
	Product Name: Flavopiridol Order number: RT-R09-149 CAS: 146426-40-6 Purity: >=95% Appearance: MF: C21H20ClNO5 MW: 401.843 MP: 169.5 oC (HCl, M.I.) oC Description: This substance inhibits cyclin-dependent kinases (CDKs) by competing with adenosine triphosphate (ATP) for the active site of each kinase. Login to check availability and price information.
	Product Name: Docetaxel trihydrate Order number: RT-R09-154 CAS: 148408-66-6 Purity: >=95% Appearance: solid MF: C43H59NO17 MW: 861.935 MP: 232 (M.I.) oC Description: This inhibitor of microtubular deploymerization also interacts with bcl-2/bcl-xL gene expression. Login to check availability and price information.
	Product Name: 7-ethyl-10-hydroxycamptothecin (SN-38), 99 Order number: 50P114089 CAS: 86639-52-3 Purity: >=95% Appearance: solid MF: C22H20N2O5 MW: 392.411 MP: n.a. oC Description: This compound is a potent polymerase I inhibitor, causing double-strand DNA to break. Login to check availability and price information.
	Product Name: (S)-4-ethyl-4,9-dihydroxy-1,12-dihydro-14H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H)-dione Order number: 50P550528 CAS: 19685-09-7 Purity: >=95% Appearance: solid MF: C20H16N2O5 MW: 364.357 MP: n.a. oC Description: This compound is a potent polymerase I inhibitor, causing double-strand DNA to break. Login to check availability and price information.

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