We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-2-methylhept-6-enoic acid Order number: 201167 CAS: 288617-73-2 Purity: >=95% Appearance: solid MF: C23H25NO4 MW: 379.456 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpent-4-enoic acid Order number: 201306 CAS: 288617-71-0 Purity: >=95% Appearance: solid MF: C21H21NO4 MW: 351.402 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-4-pentenoic acid Order number: 201307 CAS: 288617-76-5 Purity: >=95% Appearance: solid MF: C21H21NO4 MW: 351.402 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-6-heptenoic acid Order number: 201308 CAS: 288617-77-6 Purity: >=95% Appearance: solid MF: C23H25NO4 MW: 379.456 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-9-decenoic acid Order number: 201309 CAS: 288617-75-4 Purity: >=95% Appearance: solid MF: C26H31NO4 MW: 421.537 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-9-decenoic acid Order number: 201310 CAS: 945212-26-0 Purity: >=95% Appearance: solid MF: C26H31NO4 MW: 421.537 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |