We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: 1-[2,5-Anhydro-4-C-(hydroxymethyl)-a-L-lyxofuranosyl]-2,4(1H,3H)-pyrimidinedione Order number: 204505 CAS: 705967-67-5 Purity: >=95% Appearance: solid MF: C18H19N5O4 MW: 369.381 MP: n.a. oC Description: This hexitol nucleic acid (HNA) building block contains the standard nucleoside base, but with a 1',5'-anhydrohexitol backbone. HNAs are found in antisense and siRNA applications. |
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Product Name: 2-(6-Amino-9H-purin-9-yl)-1,5-anhydro-2-deoxy-4,6-O-[(R)-phenylmethylene]-D-altritol Order number: 204506 CAS: 705967-83-5 Purity: >=95% Appearance: solid MF: C18H19N5O5 MW: 385.38 MP: n.a. oC Description: This hexitol nucleic acid (HNA) building block contains the standard nucleoside base, but with a 1',5'-anhydrohexitol backbone. HNAs are found in antisense and siRNA applications. |
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Product Name: 2-(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)-1,5-anhydro-2-deoxy-4,6-O-[(R)-phenylmethylene]-D-altritol Order number: 204507 CAS: 401906-98-7 Purity: >=95% Appearance: solid MF: C17H18N2O6 MW: 346.339 MP: n.a. oC Description: This hexitol nucleic acid (HNA) building block contains the standard nucleoside base, but with a 1',5'-anhydrohexitol backbone. HNAs are found in antisense and siRNA applications. |
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Product Name: 1,5-Anhydro-2-deoxy-2-(3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl)-4,6-O-[(R)-phenylmethylene]-D-altritol Order number: 204508 CAS: 937031-51-1 Purity: >=95% Appearance: solid MF: C17H19N3O5 MW: 345.355 MP: n.a. oC Description: This hexitol nucleic acid (HNA) building block contains the standard nucleoside base, but with a 1',5'-anhydrohexitol backbone. HNAs are found in antisense and siRNA applications. |
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Product Name: (2R,4aR,7R,8S,8aS)-7-(2-amino-6-chloro-9H-purin-9-yl)-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-8-ol Order number: 204509 CAS: 705967-79-9 Purity: >=95% Appearance: solid MF: C18H18ClN5O4 MW: 403.823 MP: n.a. oC Description: This hexitol nucleic acid (HNA) building block contains the standard nucleoside base, but with a 1',5'-anhydrohexitol backbone. HNAs are found in antisense and siRNA applications. |
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Product Name: 4-amino-1-((2R,4aR,7R,8S,8aS)-8-hydroxy-2-phenylhexahydropyrano[3,2-d][1,3]dioxin-7-yl)-5-methylpyrimidin-2(1H)-one Order number: 204510 CAS: 937031-52-2 Purity: >=95% Appearance: solid MF: C18H21N3O5 MW: 359.382 MP: n.a. oC Description: This hexitol nucleic acid (HNA) building block contains the standard nucleoside base, but with a 1',5'-anhydrohexitol backbone. HNAs are found in antisense and siRNA applications. |