We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: 1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-2,4(1H,3H)-pyrimidinedione Order number: 204544 CAS: 109205-43-8 Purity: >=95% Appearance: solid MF: C9H13N3O4 MW: 227.22 MP: n.a. oC Description: Morpholino nucleosides in dinucleotides fight PARP-1, 2. Inhibitors stop DNA repair in cancer cells. |
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Product Name: 1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione Order number: 204545 CAS: 179073-10-0 Purity: >=95% Appearance: solid MF: C10H15N3O4 MW: 241.247 MP: n.a. oC Description: Morpholino nucleosides in dinucleotides fight PARP-1, 2. Inhibitors stop DNA repair in cancer cells. |
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Product Name: N-[1,2-Dihydro-1-[(2R,6S)-6-(hydroxymethyl)-2-morpholinyl]-2-oxo-4-pyrimidinyl]-benzamide Order number: 204546 CAS: 125455-77-8 Purity: >=95% Appearance: solid MF: C16H18N4O4 MW: 330.344 MP: n.a. oC Description: Morpholino nucleosides in dinucleotides fight PARP-1, 2. Inhibitors stop DNA repair in cancer cells. |
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Product Name: N-[9-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-9H-purin-6-yl]-benzamide Order number: 204547 CAS: 139290-78-1 Purity: >=95% Appearance: solid MF: C17H18N6O3 MW: 354.37 MP: n.a. oC Description: Morpholino nucleosides in dinucleotides fight PARP-1, 2. Inhibitors stop DNA repair in cancer cells. |
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Product Name: N-[6,9-Dihydro-9-[(2R,6S)-6-(hydroxymethyl)-2-morpholinyl]-6-oxo-1H-purin-2-yl]-2-methyl-propanamide Order number: 204548 CAS: 956139-23-4 Purity: >=95% Appearance: solid MF: C14H20N6O4 MW: 336.352 MP: n.a. oC Description: Morpholino nucleosides in dinucleotides fight PARP-1, 2. Inhibitors stop DNA repair in cancer cells. |