We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: D-Arg(Me, Me)-OH (symmetrical) Order number: 204484 CAS: 190784-53-5 Purity: >=95% Appearance: solid MF: C8H18N4O2 MW: 202.258 MP: n.a. oC Description: This Fmoc-protected solid-phase amenable amino acid carries a protonatable side chain that may be useful for tuning cellular permeability of peptides. |
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Product Name: Fmoc-D-Arg(Me, Me)-OH (asymmetrical) Order number: 204486 CAS: N/A Purity: >=95% Appearance: solid MF: C23H28N4O4 MW: 424.501 MP: n.a. oC Description: This Fmoc-protected solid-phase amenable amino acid carries a protonatable side chain that may be useful for tuning cellular permeability of peptides. |
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Product Name: Fmoc-Lys(Me2)-OH hydrochloride salt Order number: 204487 CAS: 252049-10-8 Purity: >=95% Appearance: solid MF: C23H28N2O4 MW: 396.487 MP: n.a. oC Description: This Fmoc-protected solid-phase amenable amino acid carries a protonatable side chain that may be useful for tuning cellular permeability of peptides. |
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Product Name: Fmoc-Lys(IVDDE)-OH Order number: 204488 CAS: 204777-78-6 Purity: >=95% Appearance: solid MF: C34H42N2O6 MW: 574.718 MP: n.a. oC Description: It carries a protonatable side chain that may be useful for tuning cellular permeability of the peptides. The epsilon amine may be used also to form lactam to enhance helicity. |
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Product Name: Fmoc-STA-OH Order number: 204648 CAS: 158257-40-0 Purity: >=95% Appearance: solid MF: C23H27NO5 MW: 397.471 MP: 92-94 oC Description: This Fmoc-protected solid-phase amenable amino acid is a key repeating unit of peptid,e pepstatin, that inhibits cathepsin E. |
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Product Name: (S)-2-Amino-N,3,3-trimethylbutanamide Order number: 204649 CAS: 89226-12-0 Purity: >=95% Appearance: solid MF: C7H16N2O MW: 144.218 MP: n.a. oC Description: Steric amino acid to form stable peptide bond against proteolytic breakdown. |