We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: Fmoc-alpha-methyl-L-leucine Order number: 204659 CAS: 312624-65-0 Purity: >=95% Appearance: solid MF: C22H25NO4 MW: 367.445 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: Fmoc-L-isovaline Order number: 204660 CAS: 857478-30-9 Purity: >=95% Appearance: solid MF: C20H21NO4 MW: 339.391 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: Fmoc-D-isovaline Order number: 204661 CAS: 1231709-21-0 Purity: >=95% Appearance: solid MF: C20H21NO4 MW: 339.391 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: Boc-L-isovaline Order number: 204662 CAS: 151171-11-8 Purity: >=95% Appearance: solid MF: C10H19NO4 MW: 217.265 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: Boc-D-isovaline Order number: 204663 CAS: 123254-58-0 Purity: >=95% Appearance: solid MF: C10H19NO4 MW: 217.265 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (S)-2-amino-2-methylbutanoic acid Order number: 204664 CAS: 595-40-4 Purity: >=95% Appearance: solid MF: C5H11NO2 MW: 117.148 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |