We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: Sodium ((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl dihydrogentriphosphate Order number: 211734 CAS: 74299-50-6 Purity: 98% Appearance: SOLID MF: C10H14N5Na2O12P3 MW: 535.1 MP: n.a. oC Description: This is a useful building block for biosynthesis of nucleic acids. |
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Product Name: Adenosine 5?-O-(2-Thiodiphosphate), Trilithium Salt Order number: 211735 CAS: 73536-95-5 Purity: n.a.% Appearance: n.a. MF: C10H15N5O9P2S MW: 443.3 MP: n.a. oC Description: This is a useful material for nucleotide chemistry and biology. |
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Product Name: 5-PHOSPHO-ALPHA-D-RIBOSYL DIPHOSPHATE SODIUM SALT Order number: 211738 CAS: 108321-05-7 Purity: ?75% Appearance: SOLID MF: C5H11Na2O14P3 MW: 434 MP: n.a. oC Description: This is a useful material for nucleotide chemistry and biology. |
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Product Name: UDP-ALPHA-D-N-ACETYLGALACTOSAMINE, DISODIUM SALT Order number: 211740 CAS: 108320-87-2 Purity: 98% Appearance: SOLID MF: C17H25N3Na2O17P2 MW: 651.3 MP: n.a. oC Description: This is a useful material for nucleotide chemistry and biology. |
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Product Name: 5-FLUORO-2'-DEOXYURIDINE 5'-MONOPHOSPHATE SODIUM SALT Order number: 211741 CAS: 103226-10-4 Purity: 97% Appearance: n.a. MF: C9H10FN2Na2O8P MW: 370.1 MP: n.a. oC Description: This is a useful material for nucleotide chemistry and biology. |
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Product Name: 5'-O-(4,4-Dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]uridine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Order number: 211745 CAS: 118362-03-1 Purity: 97% Appearance: SOLID MF: C45H61N4O9PSi MW: 861 MP: n.a. oC Description: This is a useful building block for nucleotide synthesis on solid support. |