We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: (2S)-4-Azido-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-butanoic acid Order number: 204413 CAS: 942518-20-9 Purity: >=95% Appearance: solid MF: C19H18N4O4 MW: 366.377 MP: n.a. oC Description: The azido side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a click chemistry |
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Product Name: N6-Diazo-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-2-methyl-L-lysine Order number: 204415 CAS: 1050501-64-8 Purity: >=95% Appearance: solid MF: C22H24N4O4 MW: 408.458 MP: n.a. oC Description: The azido side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a click chemistry |
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Product Name: (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-7-azidoheptanoic acid Order number: 204416 CAS: 1191429-12-5 Purity: >=95% Appearance: solid MF: C23H26N4O4 MW: 422.485 MP: n.a. oC Description: The azido side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a click chemistry |
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Product Name: (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-8-azidooctanoic acid Order number: 204417 CAS: 1191429-14-7 Purity: >=95% Appearance: solid MF: C24H28N4O4 MW: 436.512 MP: n.a. oC Description: The azido side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a click chemistry |
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Product Name: (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-4-pentynoic acid Order number: 204418 CAS: 1198791-65-9 Purity: >=95% Appearance: solid MF: C21H19NO4 MW: 349.386 MP: n.a. oC Description: The alkynyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a click chemistry |
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Product Name: (R)-N-Fmoc-2-(3'-butenyl)alanine Order number: 204433 CAS: 1311933-82-0 Purity: >=95% Appearance: solid MF: C22H23NO4 MW: 365.429 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |