Amino Acids, Nucleosides and Nucleotides

Amino Acids

We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.

Nucleosides and Nucleoside Phosphoramidites

We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.

Nucleotides

dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.

Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.

Amino Acids for Stapled Peptides

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Structure	Details
	Product Name: (S)-N-Fmoc-2-(5'-hexenyl)alanine Order number: 204463 CAS: 288617-74-3 Purity: >=95% Appearance: solid MF: C24H27NO4 MW: 393.483 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. Login to check availability and price information.
	Product Name: (R)-N-Fmoc-2-(5'-hexenyl)alanine Order number: 204464 CAS: 288617-78-7 Purity: >=95% Appearance: solid MF: C24H27NO4 MW: 393.483 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. Login to check availability and price information.
	Product Name: (S)-N-Fmoc-2-(6'-heptenyl)alanine Order number: 204465 CAS: 1311933-83-1 Purity: >=95% Appearance: solid MF: C25H29NO4 MW: 407.51 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. Login to check availability and price information.
	Product Name: (S)-N-Fmoc-allyl-glycine Order number: 204467 CAS: 146549-21-5 Purity: >=95% Appearance: solid MF: C20H19NO4 MW: 337.375 MP: n.a. oC Description: The alkenyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a ring-closure metathesis process. Login to check availability and price information.
	Product Name: (R)-N-Fmoc-allyl-glycine Order number: 204468 CAS: 170642-28-1 Purity: >=95% Appearance: solid MF: C20H19NO4 MW: 337.375 MP: n.a. oC Description: The alkenyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a ring-closure metathesis process. Login to check availability and price information.
	Product Name: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)hex-5-enoic acid Order number: 204469 CAS: 851909-08-5 Purity: >=95% Appearance: solid MF: C21H21NO4 MW: 351.402 MP: n.a. oC Description: The alkenyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a ring-closure metathesis process. Login to check availability and price information.

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