We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: (R)-N-Fmoc-2-(7'-octenyl)glycine Order number: 204476 CAS: 1191429-20-5 Purity: >=95% Appearance: solid MF: C25H29NO4 MW: 407.51 MP: n.a. oC Description: The alkenyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a ring-closure metathesis process. |
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Product Name: N-Fmoc-2-amino-2-(2-propenyl)-4-pentenoic acid Order number: 204477 CAS: 1311992-97-8 Purity: >=95% Appearance: solid MF: C23H23NO4 MW: 377.44 MP: n.a. oC Description: Having two alkenyl groups, this amino acid may have more versatility in the study of stappled peptides. |
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Product Name: N-Fmoc-2-amino-2-(3-butenyl)hex-5-enoic acid Order number: 204478 CAS: 1311992-98-9 Purity: >=95% Appearance: solid MF: C25H27NO4 MW: 405.494 MP: n.a. oC Description: Having two alkenyl groups, this amino acid may have more versatility in the study of stappled peptides. |
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Product Name: (2S)-N-Fmoc-5-azidopentenoic acid Order number: 204479 CAS: 1097192-04-5 Purity: >=95% Appearance: solid MF: C20H20N4O4 MW: 380.404 MP: n.a. oC Description: The azido side chain of this product can be tied (clicked) with alkynyl side chain of another amino acid in peptide backbone via a click chemistry. |
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Product Name: N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-diazo-L-lysine Order number: 204480 CAS: 159610-89-6 Purity: >=95% Appearance: solid MF: C21H22N4O4 MW: 394.431 MP: n.a. oC Description: The azido side chain of this product can be tied (clicked) with alkynyl side chain of another amino acid in peptide backbone via a click chemistry. |
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Product Name: (S)-N-Fmoc-2-(2'-propynyl)glycine Order number: 204482 CAS: 198561-07-8 Purity: >=95% Appearance: solid MF: C20H17NO4 MW: 335.359 MP: n.a. oC Description: The alkynyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via click chemistry. |