We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: N-Fmoc-2-amino-2-(pent-4-enyl)dec-9-enoic acid Order number: 204513 CAS: 1211504-14-1 Purity: >=95% Appearance: solid MF: C30H37NO4 MW: 475.629 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: (S)-2-(2'-Propylenyl)alanine Order number: 204514 CAS: 96886-55-4 Purity: >=95% Appearance: solid MF: C6H11NO2 MW: 129.159 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: (R)-2-(2'-Propylenyl)alanine Order number: 204515 CAS: 96886-56-5 Purity: >=95% Appearance: solid MF: C6H11NO2 MW: 129.159 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: (S)-2-(3'-Butenyl)alanine Order number: 204516 CAS: 1011309-60-0 Purity: >=95% Appearance: solid MF: C7H13NO2 MW: 143.186 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: (R)- 2-(3'-Butenyl)alanine Order number: 204517 CAS: na Purity: >=95% Appearance: solid MF: C7H13NO2 MW: 143.186 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: (S)- 2-(5'-Pentenyl)alanine Order number: 204518 CAS: 1011309-61-7 Purity: >=95% Appearance: solid MF: C8H15NO2 MW: 157.213 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |