We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: 1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furyl]pyrimidine-2,4(1H,3H)-dione Order number: 212153 CAS: 4348-61-2 Purity: ?98% Appearance: n.a. MF: C9H12N2O6 MW: 244.2 MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |
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Product Name: Thymidine 5?-monophosphate p-nitrophenyl Order number: 212154 CAS: 98179-10-3 Purity: ?98 (HPLC)% Appearance: n.a. MF: C16H18N3NaO10P MW: 466.3 MP: n.a. oC Description: This is a useful material for nucleotide chemistry and biology. |
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Product Name: 2'-FLUORO-5'-O-DMT-2'-DEOXYINOSINE-3'-CE-PHOSPHORAMIDITE Order number: 212155 CAS: 2245842-16-2 Purity: 98% Appearance: n.a. MF: MW: MP: n.a. oC Description: This is a useful building block for nucleotide synthesis on solid support. |