We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: (R)-N-Fmoc-alpha-methylasparagine Order number: 204671 CAS: 1403590-50-0 Purity: >=95% Appearance: solid MF: C20H20N2O5 MW: 368.389 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (S)-N-alpha-Fmoc-N-omega-Boc-alpha-methyllysine Order number: 204672 CAS: 1202003-49-3 Purity: >=95% Appearance: solid MF: C27H34N2O6 MW: 482.577 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6-((tert-butoxycarbonyl)amino)-2-methylhexanoic acid Order number: 204673 CAS: 1315449-94-5 Purity: >=95% Appearance: solid MF: C27H34N2O6 MW: 482.577 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (S)-N-Fmoc-alpha-methyl-2-fluorophenylalaine Order number: 204674 CAS: 1172127-44-4 Purity: >=95% Appearance: solid MF: C25H22FNO4 MW: 419.452 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (R)-N-Fmoc-alpha-methyl-2-fluorophenylalaine Order number: 204675 CAS: 1315449-93-4 Purity: >=95% Appearance: solid MF: C25H22FNO4 MW: 419.452 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (S)-alpha-Methyl-3-fluorophenylalaine Order number: 204676 CAS: 130855-56-0 Purity: >=95% Appearance: solid MF: C10H12FNO2 MW: 197.209 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |