Amino Acids, Nucleosides and Nucleotides

Amino Acids

We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.

Nucleosides and Nucleoside Phosphoramidites

We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.

Nucleotides

dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.

Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.

  • Amino Acids for Stapled Peptides
  • 2-Methylated Amino Acids
  • Peptide Labeling
  • Other Unnatural Amino Acids
  • Nucleosides
  • HNA Precursors
  • Morpholino Nucleosides
  • Nucleoside Phosphoramidites and Nucleotides
  • Nucleosides

    Structure Details
    Product Name: Guanosine-?9-?17N, N-?(2-?methyl-?1-?oxopropyl)?-?, 2',?3'-?diacetate
    Order number: 212151
    CAS: 163586-86-5
    Purity: 98%
    Appearance: OFF-WHITE POWDER?
    MF: C18H23N5O8
    MW: 437.4
    MP: n.a. oC

    Description:
    This is a useful material for nucleoside and nucleotide chemistry.
    Product Name: (E)-Ethyl 3-(1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylate
    Order number: 212152
    CAS: 123881-85-6
    Purity: 98%
    Appearance: SOLID
    MF: C14H18N2O8
    MW: 342.3
    MP: n.a. oC

    Description:
    This is a useful material for nucleoside and nucleotide chemistry.
    Product Name: 1-[(2R,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydro-2-furyl]pyrimidine-2,4(1H,3H)-dione
    Order number: 212153
    CAS: 4348-61-2
    Purity: ?98%
    Appearance: n.a.
    MF: C9H12N2O6
    MW: 244.2
    MP: n.a. oC

    Description:
    This is a useful material for nucleoside and nucleotide chemistry.