We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: Uridine, 2'-deoxy-3'-O-[(1,1-dimethylethyl)dimethylsilyl]-2'-fluoro-4'-C-(hydroxymethyl)- Order number: 211772 CAS: 1445379-61-2 Purity: 98% Appearance: n.a. MF: C16H27FN2O6Si MW: 390.5 MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |
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Product Name: .alpha.-D-Mannopyranose, 2,3,4,6-tetrabenzoate 1-(2,2,2-trichloroethanimidate) Order number: 211776 CAS: 183901-63-5 Purity: 97% Appearance: SOLID MF: MW: MP: n.a. oC Description: This is a useful starting material for nucleoside chemistry. |
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Product Name: Serotonin ?-D-Glucuronide Order number: 211777 CAS: 18186-43-1 Purity: 97% Appearance: SOLID MF: MW: MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |
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Product Name: nicotinic acid ribonucleoside Order number: 211778 CAS: 17720-18-2 Purity: 97% Appearance: SOLID MF: C11H13NO6 MW: 255.2 MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |
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Product Name: 2',3',5'-TRI-O-BENZOYLURIDINE Order number: 211779 CAS: 1748-04-5 Purity: n.a.% Appearance: SOLID MF: C30H24N2O9 MW: 556.5 MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |
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Product Name: 5'-O-(4,4-Dimethoxytrityl)-N-[[4-(tert-butyl)phenoxy]acetyl]-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Order number: 211783 CAS: 179486-26-1 Purity: 95% Appearance: n.a. MF: C52H64N5O10P MW: 950.1 MP: n.a. oC Description: This is a useful building block for nucleotide synthesis on solid support. |