We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: 1-[2,5-Anhydro-4-C-(hydroxymethyl)-a-L-lyxofuranosyl]-2,4(1H,3H)pyrimidinedione Order number: 204427 CAS: 200435-92-3 Purity: >=95% Appearance: solid MF: C10H12N2O6 MW: 256.214 MP: n.a. oC Description: This 2'-modified nucleoside with a cross bond is useful for biological and medicinal studies. |
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Product Name: 4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine Order number: 204431 CAS: 84955-31-7 Purity: >=95% Appearance: solid MF: C6H5ClN4 MW: 168.584 MP: n.a. oC Description: This is a deaza precursor base for glycosidation. |
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Product Name: (R)-N-Fmoc-2-(3'-butenyl)alanine Order number: 204433 CAS: 1311933-82-0 Purity: >=95% Appearance: solid MF: C22H23NO4 MW: 365.429 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: 4-(Methylthio)-2-pyridinamine Order number: 204435 CAS: 38240-26-5 Purity: >=95% Appearance: solid MF: C6H8N2S MW: 140.204 MP: n.a. oC Description: Pyridine intermediate. |
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Product Name: (S)-N-Fmoc-2-(5'-hexenyl)alanine Order number: 204463 CAS: 288617-74-3 Purity: >=95% Appearance: solid MF: C24H27NO4 MW: 393.483 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: (R)-N-Fmoc-2-(5'-hexenyl)alanine Order number: 204464 CAS: 288617-78-7 Purity: >=95% Appearance: solid MF: C24H27NO4 MW: 393.483 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |