We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: Adenosine, 2'-deoxy-3',5'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]- Order number: 212105 CAS: 51549-32-7 Purity: 98% Appearance: SOLID MF: C22H41N5O3Si2 MW: 479.8 MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |
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Product Name: 4-Amino-1-[3,5-bis-O-(4-chlorobenzoyl)-2-deoxy-D-erythro-pen Order number: 212106 CAS: 1193165-26-2 Purity: 98% Appearance: n.a. MF: C22H18Cl2N4O6 MW: 505.3 MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |
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Product Name: 2 -O-Methyl-P-thiouridylyl-(3 ?5 )-2 -deoxyadenosine Order number: 212107 CAS: 475650-36-3 Purity: 98% Appearance: SOLID MF: C20H26N7O10PS MW: 587.5 MP: n.a. oC Description: This is a useful material for nucleotide chemistry and biology. |
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Product Name: 5-(Methoxycarbonylmethyl)-2-thiouridine Order number: 212108 CAS: 20299-15-4 Purity: 95% Appearance: n.a. MF: MW: MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |
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Product Name: 7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-fluoro-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one Order number: 212109 CAS: 952429-17-3 Purity: 95% Appearance: n.a. MF: C11H12FN3O5 MW: 285.2 MP: n.a. oC Description: Useful building block for nucleoside and nucleotide chemistry |
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Product Name: N4-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine 3'-CE phosphoramidite Order number: 212112 CAS: 142808-44-4 Purity: 97% Appearance: n.a. MF: C46H50F2N5O8P MW: 869.9 MP: n.a. oC Description: This is a useful building block for nucleotide synthesis on solid support. |