We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: (S)-N-Fmoc-2-(5'-pentenyl)glycine Order number: 204472 CAS: 1251904-51-4 Purity: >=95% Appearance: solid MF: C23H25NO4 MW: 379.456 MP: n.a. oC Description: The alkenyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a ring-closure metathesis process. |
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Product Name: (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)oct-7-enoic acid Order number: 204473 CAS: 1208226-88-3 Purity: >=95% Appearance: solid MF: C23H25NO4 MW: 379.456 MP: n.a. oC Description: The alkenyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a ring-closure metathesis process. |
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Product Name: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)non-8-enoic acid Order number: 204474 CAS: 1058705-57-9 Purity: >=95% Appearance: solid MF: C24H27NO4 MW: 393.483 MP: n.a. oC Description: The alkenyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a ring-closure metathesis process. |
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Product Name: (S)-N-Fmoc-2-(7'-octenyl)glycine Order number: 204475 CAS: 1262886-64-5 Purity: >=95% Appearance: solid MF: C25H29NO4 MW: 407.51 MP: n.a. oC Description: The alkenyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a ring-closure metathesis process. |
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Product Name: (R)-N-Fmoc-2-(7'-octenyl)glycine Order number: 204476 CAS: 1191429-20-5 Purity: >=95% Appearance: solid MF: C25H29NO4 MW: 407.51 MP: n.a. oC Description: The alkenyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via a ring-closure metathesis process. |
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Product Name: N-Fmoc-2-amino-2-(2-propenyl)-4-pentenoic acid Order number: 204477 CAS: 1311992-97-8 Purity: >=95% Appearance: solid MF: C23H23NO4 MW: 377.44 MP: n.a. oC Description: Having two alkenyl groups, this amino acid may have more versatility in the study of stappled peptides. |