We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: N-Fmoc-2-amino-2-(3-butenyl)hex-5-enoic acid Order number: 204478 CAS: 1311992-98-9 Purity: >=95% Appearance: solid MF: C25H27NO4 MW: 405.494 MP: n.a. oC Description: Having two alkenyl groups, this amino acid may have more versatility in the study of stappled peptides. |
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Product Name: (2S)-N-Fmoc-5-azidopentenoic acid Order number: 204479 CAS: 1097192-04-5 Purity: >=95% Appearance: solid MF: C20H20N4O4 MW: 380.404 MP: n.a. oC Description: The azido side chain of this product can be tied (clicked) with alkynyl side chain of another amino acid in peptide backbone via a click chemistry. |
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Product Name: N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-diazo-L-lysine Order number: 204480 CAS: 159610-89-6 Purity: >=95% Appearance: solid MF: C21H22N4O4 MW: 394.431 MP: n.a. oC Description: The azido side chain of this product can be tied (clicked) with alkynyl side chain of another amino acid in peptide backbone via a click chemistry. |
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Product Name: (S)-N-Fmoc-2-(2'-propynyl)glycine Order number: 204482 CAS: 198561-07-8 Purity: >=95% Appearance: solid MF: C20H17NO4 MW: 335.359 MP: n.a. oC Description: The alkynyl side chain of this product can be tied (stapled) with another adjacent alkenyl side chain pre-existed on the peptide backbone via click chemistry. |
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Product Name: 2-O-Ethylthymidine Order number: 204498 CAS: 59495-21-5 Purity: >=95% Appearance: solid MF: C12H18N2O5 MW: 270.285 MP: n.a. oC Description: Research nucleoside for biochemistry and drug discovery uses. |
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Product Name: 2-O-Methylthymidine Order number: 204499 CAS: 37085-48-6 Purity: >=95% Appearance: solid MF: C11H16N2O5 MW: 256.258 MP: n.a. oC Description: Research nucleoside for biochemistry and drug discovery uses. |