We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: N-Benzoyl-5'-O-DMTr-2'-O-(2- Methoxyethyl)cytidine Order number: 204538 CAS: 251647-49-1 Purity: >=95% Appearance: solid MF: C40H41N3O9 MW: 707.78 MP: n.a. oC Description: This is a nucleoside intermediate. |
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Product Name: 5'-O-DMTr- 2'-O-(2-Methoxyethyl)uridine Order number: 204539 CAS: 251647-51-5 Purity: >=95% Appearance: solid MF: C33H36N2O9 MW: 604.656 MP: n.a. oC Description: This is a nucleoside intermediate. |
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Product Name: 6-Chloro-7-Deazapurine-D-riboside Order number: 204540 CAS: 16754-80-4 Purity: >=95% Appearance: solid MF: C11H12ClN3O4 MW: 285.684 MP: n.a. oC Description: Deazpurine derived nucleosides are study subjects for antiviral activities. |
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Product Name: Tubercidin Order number: 204541 CAS: 69-33-0 Purity: >=95% Appearance: solid MF: C11H14N4O4 MW: 266.257 MP: n.a. oC Description: Tubercidin and deazapurine nucleosides have been studied for activities against Covid (SARS-CoV-2) virus. |
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Product Name: 1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-2,4(1H,3H)-pyrimidinedione Order number: 204544 CAS: 109205-43-8 Purity: >=95% Appearance: solid MF: C9H13N3O4 MW: 227.22 MP: n.a. oC Description: Morpholino nucleosides in dinucleotides fight PARP-1, 2. Inhibitors stop DNA repair in cancer cells. |
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Product Name: 1-[(2R,6S)-6-(Hydroxymethyl)-2-morpholinyl]-5-methyl-2,4(1H,3H)-pyrimidinedione Order number: 204545 CAS: 179073-10-0 Purity: >=95% Appearance: solid MF: C10H15N3O4 MW: 241.247 MP: n.a. oC Description: Morpholino nucleosides in dinucleotides fight PARP-1, 2. Inhibitors stop DNA repair in cancer cells. |