We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: 1,5-Anhydro-D-glucitol Order number: 204571 CAS: 154-58-4 Purity: >=95% Appearance: solid MF: C6H12O5 MW: 164.157 MP: n.a. oC Description: Sugar building block. |
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Product Name: (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methylnon-8-enoic acid Order number: 204625 CAS: 1311933-84-2 Purity: >=95% Appearance: solid MF: C25H29NO4 MW: 407.51 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: D-Arg(Me, Me)-OH (asymmetrical) Order number: 204627 CAS: 783265-75-8 Purity: >=95% Appearance: solid MF: C8H18N4O2 MW: 202.258 MP: n.a. oC Description: N-Methylated Arg is believed a derivative of Arg in the NO pathway. As a building block, it has found applications for making peptides with nervous system activities. |
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Product Name: Fmoc-D-Arg(Me, Me)-OH (symmetrical) Order number: 204628 CAS: n/a Purity: >=95% Appearance: solid MF: C23H28N4O4 MW: 424.501 MP: n.a. oC Description: N-Methylated Arg is believed a derivative of Arg in the NO pathway. As a building block, it has found applications for making peptides with nervous system activities. |
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Product Name: Fmoc-L-HomoArg(Pbf)-OH Order number: 204630 CAS: 401915-53-5 Purity: >=95% Appearance: solid MF: C35H42N4O7S MW: 662.802 MP: n.a. oC Description: HomoArgine is derived from Arg in NO pathway. |
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Product Name: Fmoc-L-HomoArg(Pmc)-OH Order number: 204631 CAS: 214852-52-5 Purity: >=95% Appearance: solid MF: C36H44N4O7S MW: 676.829 MP: n.a. oC Description: L-Homoarginine is the naturally-occurring enantiomer. Physiologically, homoarginine serves a substrate of NOS. It may participate in pathways that Arg does. |