We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: (R)-2-amino-2-methylbutanoic acid Order number: 204665 CAS: 3059-97-0 Purity: >=95% Appearance: solid MF: C5H11NO2 MW: 117.148 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (S)-N-Fmoc-alpha-methylaspartic acid -4-(tert-butyl) ester Order number: 204666 CAS: 1072845-47-6 Purity: >=95% Appearance: solid MF: C24H27NO6 MW: 425.481 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (R)-N-Fmoc-alpha-methylaspartic acid -4-(tert-butyl) ester Order number: 204667 CAS: 1231709-26-4 Purity: >=95% Appearance: solid MF: C24H27NO6 MW: 425.481 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (S)-alpha-Methylaspartic acid -4-(tert-butyl) ester Order number: 204668 CAS: 1217977-71-3 Purity: >=95% Appearance: solid MF: C9H17NO4 MW: 203.238 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (R)-alpha-Methylaspartic acid -4-(tert-butyl) ester Order number: 204669 CAS: 1231709-25-3 Purity: >=95% Appearance: solid MF: C9H17NO4 MW: 203.238 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (S)-N-Fmoc-alpha-methylasparagine Order number: 204670 CAS: 1403590-49-7 Purity: >=95% Appearance: solid MF: C20H19NO6 MW: 369.373 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |