We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: Fmoc-L-4-(O-tert-butylcarboxymethyl)phe-OH Order number: 204642 CAS: 222842-99-1 Purity: >=95% Appearance: solid MF: C30H31NO6 MW: 501.579 MP: n.a. oC Description: Phenylalanine in bacterial proteins can be substituted with various unnatural amino acids |
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Product Name: (S)-Fmoc-2-amino-heptanedioic acid-7-(tert-butyl)ester Order number: 204644 CAS: 159751-46-9 Purity: >=95% Appearance: solid MF: C26H31NO6 MW: 453.535 MP: n.a. oC Description: This amino acid has a longer backbone than glutamine by two carbons. |
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Product Name: Fmoc-N-Me-Glu(OtBu)-OH Order number: 204647 CAS: 200616-40-6 Purity: >=95% Appearance: solid MF: C25H29NO6 MW: 439.508 MP: n.a. oC Description: This is a N-methylated glutamine. |
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Product Name: (S)-alpha-Methyl-4-Iodophenylalanine Order number: 204690 CAS: 1215092-16-2 Purity: >=95% Appearance: solid MF: C10H12INO2 MW: 305.115 MP: n.a. oC Description: This alpha-methylated phenylalanine-like amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (R)-alpha-Methyl-4-Iodophenylalaine Order number: 204691 CAS: 213203-06-6 Purity: >=95% Appearance: solid MF: C10H12INO2 MW: 305.115 MP: n.a. oC Description: This alpha-methylated phenylalanine-like amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (S)-alpha-Methyltyrosine Order number: 204692 CAS: 672-87-7 Purity: >=95% Appearance: solid MF: C10H13NO3 MW: 195.218 MP: n.a. oC Description: This alpha-methylated phenylalanine-like amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |