We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: (R)-alpha-Methyltyrosine Order number: 204693 CAS: 672-86-6 Purity: >=95% Appearance: solid MF: C10H13NO3 MW: 195.218 MP: n.a. oC Description: This alpha-methylated phenylalanine-like amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (S)-N-Fmoc-(N-Boc)-alpha-methyltryptophan Order number: 204696 CAS: 1315449-98-9 Purity: >=95% Appearance: solid MF: C32H32N2O6 MW: 540.616 MP: n.a. oC Description: This alpha-methylated phenylalanine-like amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (R)-N-Fmoc-(N-Boc)-alpha-methyltryptophan Order number: 204697 CAS: 220155-72-6 Purity: >=95% Appearance: solid MF: C32H32N2O6 MW: 540.616 MP: n.a. oC Description: This alpha-methylated phenylalanine-like amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: 2,5,7-Tris-tert-butyl-L-tryptophan Order number: 204698 CAS: 62029-63-4 Purity: >=95% Appearance: solid MF: C23H36N2O2 MW: 372.553 MP: n.a. oC Description: This t-butylated tryptophan amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. As is it can be a good candidate for solution-phase peptide chemistry. |
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Product Name: (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-4-pentynoic acid Order number: 204700 CAS: 1198791-58-0 Purity: >=95% Appearance: solid MF: C21H19NO4 MW: 349.386 MP: n.a. oC Description: The alkynyl side chain of this product can be tied with an adjacent azido side chain pre-existed on the peptide backbone via click chemistry. |
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Product Name: Di-arginine oxoglurate Order number: RT-Diaog CAS: 5256-76-8 Purity: >=95% Appearance: solid MF: C17H34N8O9 MW: 494.506 MP: n.a. oC Description: L-arginine offers potential cardiovascular benefits through its antiatherogenic, anti-ischemic, antiplatelet, and antithrombotic properties. |