We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: Fmoc-L-4-(O-tert-butylcarboxymethyl)phe-OH Order number: 204642 CAS: 222842-99-1 Purity: >=95% Appearance: solid MF: C30H31NO6 MW: 501.579 MP: n.a. oC Description: Phenylalanine in bacterial proteins can be substituted with various unnatural amino acids |
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Product Name: (S)-Fmoc-2-amino-heptanedioic acid-7-(tert-butyl)ester Order number: 204644 CAS: 159751-46-9 Purity: >=95% Appearance: solid MF: C26H31NO6 MW: 453.535 MP: n.a. oC Description: This amino acid has a longer backbone than glutamine by two carbons. |
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Product Name: Fmoc-N-Me-Glu(OtBu)-OH Order number: 204647 CAS: 200616-40-6 Purity: >=95% Appearance: solid MF: C25H29NO6 MW: 439.508 MP: n.a. oC Description: This is a N-methylated glutamine. |
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Product Name: 2,5,7-Tris-tert-butyl-L-tryptophan Order number: 204698 CAS: 62029-63-4 Purity: >=95% Appearance: solid MF: C23H36N2O2 MW: 372.553 MP: n.a. oC Description: This t-butylated tryptophan amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. As is it can be a good candidate for solution-phase peptide chemistry. |
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Product Name: Di-arginine oxoglurate Order number: RT-Diaog CAS: 5256-76-8 Purity: >=95% Appearance: solid MF: C17H34N8O9 MW: 494.506 MP: n.a. oC Description: L-arginine offers potential cardiovascular benefits through its antiatherogenic, anti-ischemic, antiplatelet, and antithrombotic properties. |
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Product Name: 4-Piperidinecarboxylic acid Order number: RT-GA-004 CAS: 498-94-2 Purity: >=95% Appearance: solid MF: C6H11NO2 MW: 129.159 MP: 336 oC Description: This is unprotected amino acid with ring constraint. |