We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: 6-Azaindole Order number: RT-R06-499 CAS: 271-29-4 Purity: >=95% Appearance: solid MF: C7H6N2 MW: 118.139 MP: n.a. oC Description: Azaindoles (pyrrolopyridine) are indole bioisosteres for pharmaceutical optimization, for binding, solubility, and ADME properties. |
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Product Name: Ethyl (3-R,S)-hydroxyl-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate Order number: RT-R07-142 CAS: 95058-92-7 Purity: >=95% Appearance: solid MF: C10H16F2O5 MW: 254.23 MP: n.a. oC Description: This is a useful difluorosugar moiety for making antiviral nucleosides. |
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Product Name: Cytidine, N-acetyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy- Order number: 211338 CAS: 100898-63-3 Purity: 96% Appearance: SOLID MF: C32H33N3O7 MW: 571.6 MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |
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Product Name: Cytidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(2-methyl-1-oxopropyl)- Order number: 211339 CAS: 100898-62-2 Purity: 99% Appearance: n.a. MF: C34H37N3O7 MW: 599.7 MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |
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Product Name: Cytidine, 2'-deoxy-2'-fluoro- Order number: 211342 CAS: 10212-20-1 Purity: 98% Appearance: SOLID MF: C9H12FN3O4 MW: 245.2 MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |
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Product Name: Cytidine, 2'-chloro-2'-deoxy- (8CI,9CI) Order number: 211343 CAS: 10212-19-8 Purity: n.a.% Appearance: n.a. MF: C9H12ClN3O4 MW: 261.7 MP: n.a. oC Description: This is a useful material for nucleoside and nucleotide chemistry. |