We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: Fmoc-(S)-octylglycine Order number: 204657 CAS: 193885-59-5 Purity: >=95% Appearance: solid MF: C25H31NO4 MW: 409.526 MP: n.a. oC Description: Fmoc-protected solid-phase amenable unnatural amino acid is used to study peptide functions. |
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Product Name: 3-(3-Benzothienyl)-N-Fmoc-L-alanine Order number: 204658 CAS: 177966-60-8 Purity: >=95% Appearance: solid MF: C26H21NO4S MW: 443.517 MP: n.a. oC Description: Fmoc-protected solid-phase amenable steric amino acid is used to mimic phenylalanine and tryptophan. |
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Product Name: N6-[(tert-Butoxy)carbonyl]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-N6-methyl-L-Lysine Order number: 204396 CAS: 951695-85-5 Purity: >=95% Appearance: solid MF: C27H34N2O6 MW: 482.577 MP: n.a. oC Description: Fmoc/Boc-protected solid-phase amenable amino acid is used orthogonally to enhance peptide function. |
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Product Name: (5S)-5-Carboxy-5-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-N,N,N-trimethyl-1-pentanaminium chloride (1:1) Order number: 204397 CAS: 201004-29-7 Purity: >=95% Appearance: solid MF: C24H31ClN2O4 MW: 446.972 MP: n.a. oC Description: This Fmoc protected solid-phase amenable amino acid carries a permanent positive charge on the side chain that may be useful for tuning cellular permeability of peptides. |
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Product Name: N5-[(Methylamino)(methylimino)methyl]-L-ornithine Order number: 204398 CAS: 30344-00-4 Purity: >=95% Appearance: solid MF: C8H18N4O2 MW: 202.258 MP: n.a. oC Description: This amino acid once incorporated in peptide may enhance its cellular permeability. |
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Product Name: N5-[Bis(methylamino)methylene]-N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-ornithine Order number: 204399 CAS: 823780-66-1 Purity: >=95% Appearance: solid MF: C23H28N4O4 MW: 424.501 MP: n.a. oC Description: Fmoc-protected solid-phase amenable amino acid is used to enhance peptide function/property. |