We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: (S)-2-Amino-N,3,3-trimethylbutanamide Order number: 204649 CAS: 89226-12-0 Purity: >=95% Appearance: solid MF: C7H16N2O MW: 144.218 MP: n.a. oC Description: Steric amino acid to form stable peptide bond against proteolytic breakdown. |
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Product Name: (S)-2-Amino-2-methyl-3-phenylpropionic acid Order number: 204651 CAS: 23239-35-2 Purity: >=95% Appearance: solid MF: C10H13NO2 MW: 179.219 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (R)-2-Amino-2-methyl-3-phenylpropionic acid Order number: 204652 CAS: 17350-84-4 Purity: >=95% Appearance: solid MF: C10H13NO2 MW: 179.219 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methyl-3-phenylpropanoic acid Order number: 204653 CAS: 135944-05-7 Purity: >=95% Appearance: solid MF: C25H23NO4 MW: 401.462 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methyl-3-phenylpropanoic acid Order number: 204654 CAS: 152436-04-9 Purity: >=95% Appearance: solid MF: C25H23NO4 MW: 401.462 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: Boc-2-methyl-L-phenylalanine Order number: 204655 CAS: 53940-88-8 Purity: >=95% Appearance: solid MF: C15H21NO4 MW: 279.336 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |