We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: Fmoc-Lys(IVDDE)-OH Order number: 204488 CAS: 204777-78-6 Purity: >=95% Appearance: solid MF: C34H42N2O6 MW: 574.718 MP: n.a. oC Description: It carries a protonatable side chain that may be useful for tuning cellular permeability of the peptides. The epsilon amine may be used also to form lactam to enhance helicity. |
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Product Name: Fmoc-Lys(Dansyl)-OH Order number: 204489 CAS: 118584-90-0 Purity: >=95% Appearance: solid MF: C33H35N3O6S MW: 601.718 MP: n.a. oC Description: This Fmoc-protected solid-phase amenable amino acid carrying a fluorescent group Dansyl is a useful fluorescent peptide labeler for life sciences. |
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Product Name: Fmoc- Lys(DABCYL)-OH Order number: 204492 CAS: 146998-27-8 Purity: >=95% Appearance: solid MF: C36H37N5O5 MW: 619.722 MP: n.a. oC Description: This Fmoc-protected solid-phase amenable amino acid carrying a fluorescent group Dabcyl is a useful peptide labeler for life sciences. |
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Product Name: Fmoc-Lys(Biotin)-OH Order number: 204493 CAS: 146987-10-2 Purity: >=95% Appearance: solid MF: C31H38N4O6S MW: 594.727 MP: n.a. oC Description: This Fmoc-protected solid-phase amenable amino acid carrying a biotinyl group is a valuable peptide labeler for life sciences. |
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Product Name: 2'-Azido-2'-deoxy-5-methyl uridine Order number: 204495 CAS: 97748-75-9 Purity: >=95% Appearance: solid MF: C10H13N5O5 MW: 283.244 MP: n.a. oC Description: Under the catalysis of polymerase, the nucleoside can be incorporated into rRNA. Fluorescent probe can be attached onto the azide group via click chemistry. |
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Product Name: Fmoc-STA-OH Order number: 204648 CAS: 158257-40-0 Purity: >=95% Appearance: solid MF: C23H27NO5 MW: 397.471 MP: 92-94 oC Description: This Fmoc-protected solid-phase amenable amino acid is a key repeating unit of peptid,e pepstatin, that inhibits cathepsin E. |