We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: Boc-2-methyl-D-phenylalanine Order number: 204656 CAS: 111771-58-5 Purity: >=95% Appearance: solid MF: C15H21NO4 MW: 279.336 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: Fmoc-(S)-octylglycine Order number: 204657 CAS: 193885-59-5 Purity: >=95% Appearance: solid MF: C25H31NO4 MW: 409.526 MP: n.a. oC Description: Fmoc-protected solid-phase amenable unnatural amino acid is used to study peptide functions. |
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Product Name: 3-(3-Benzothienyl)-N-Fmoc-L-alanine Order number: 204658 CAS: 177966-60-8 Purity: >=95% Appearance: solid MF: C26H21NO4S MW: 443.517 MP: n.a. oC Description: Fmoc-protected solid-phase amenable steric amino acid is used to mimic phenylalanine and tryptophan. |
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Product Name: Fmoc-alpha-methyl-L-leucine Order number: 204659 CAS: 312624-65-0 Purity: >=95% Appearance: solid MF: C22H25NO4 MW: 367.445 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: Fmoc-L-isovaline Order number: 204660 CAS: 857478-30-9 Purity: >=95% Appearance: solid MF: C20H21NO4 MW: 339.391 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |
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Product Name: Fmoc-D-isovaline Order number: 204661 CAS: 1231709-21-0 Purity: >=95% Appearance: solid MF: C20H21NO4 MW: 339.391 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. |