Amino Acids, Nucleosides and Nucleotides

Amino Acids

We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.

Nucleosides and Nucleoside Phosphoramidites

We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.

Nucleotides

dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.

Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.

  • Amino Acids for Stapled Peptides
  • 2-Methylated Amino Acids
  • Peptide Labeling
  • Other Unnatural Amino Acids
  • Nucleosides
  • HNA Precursors
  • Morpholino Nucleosides
  • Nucleoside Phosphoramidites and Nucleotides
  • Structure Details
    Product Name: (S)-2-Amino-N,3,3-trimethylbutanamide
    Order number: 204649
    CAS: 89226-12-0
    Purity: >=95%
    Appearance: solid
    MF: C7H16N2O
    MW: 144.218
    MP: n.a. oC

    Description:
    Steric amino acid to form stable peptide bond against proteolytic breakdown.
    Product Name: (S)-2-Amino-2-methyl-3-phenylpropionic acid
    Order number: 204651
    CAS: 23239-35-2
    Purity: >=95%
    Appearance: solid
    MF: C10H13NO2
    MW: 179.219
    MP: n.a. oC

    Description:
    This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis.
    Product Name: (R)-2-Amino-2-methyl-3-phenylpropionic acid
    Order number: 204652
    CAS: 17350-84-4
    Purity: >=95%
    Appearance: solid
    MF: C10H13NO2
    MW: 179.219
    MP: n.a. oC

    Description:
    This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis.
    Product Name: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methyl-3-phenylpropanoic acid
    Order number: 204653
    CAS: 135944-05-7
    Purity: >=95%
    Appearance: solid
    MF: C25H23NO4
    MW: 401.462
    MP: n.a. oC

    Description:
    This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis.
    Product Name: (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methyl-3-phenylpropanoic acid
    Order number: 204654
    CAS: 152436-04-9
    Purity: >=95%
    Appearance: solid
    MF: C25H23NO4
    MW: 401.462
    MP: n.a. oC

    Description:
    This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis.
    Product Name: Boc-2-methyl-L-phenylalanine
    Order number: 204655
    CAS: 53940-88-8
    Purity: >=95%
    Appearance: solid
    MF: C15H21NO4
    MW: 279.336
    MP: n.a. oC

    Description:
    This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis.