Amino Acids and Nucleosides

We offer FMOC-protected unnatural amino acids for synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.

We offer nucleosides with modifications at the pyrimidine or purine base, such as 6- Thioguanine, 7-Deazaadenine, 7-Deazaguanine, 8-Azidoadenine, 8-Bromoinosine and 8- Iodoadenine, and at the sugar such as 5'-Azido-5'-deoxythymidine, 2'-Azido-2'-deoxyuridine and 2'-Azido-2'-deoxy-5-methyl uridine.

  • Amino Acids for Stapled Peptides
  • 2-Methylated Amino Acids
  • Peptide Labeling
  • Other Unnatural Amino Acids
  • Modified Nucleosides
  • HNA Precursors
  • Morpholino Nucleosides
  • Other Nucleosides & Intermediates
  • Structure Details
    Product Name: Droxidopa
    Order number: RT-R04-029
    CAS: 23651-95-8
    Purity: >=95%
    Appearance: solid
    MF: C9H11NO5
    MW: 213.189
    MP: 225 oC

    This compound can be a useful chiral starting material. Biologically, it is a substrate of dopodehydroxylase to convert to norepinephrine within sympathetic terminals.
    Product Name: Methyl-(2s,4s)-4-fluoro-2-prolinate
    Order number: RT-R06-362
    CAS: 58281-79-1
    Purity: >=95%
    Appearance: solid
    MF: C6H11ClFNO2
    MW: 183.607
    MP: n.a. oC

    The fluorine with strong inductive effect can enforce a particular ring pucker and accelerate cis/trans prolyl peptide bond isomerization, thereby providing conformational stability for peptides and proteins.
    Product Name: 6-Azaindole
    Order number: RT-R06-499
    CAS: 271-29-4
    Purity: >=95%
    Appearance: solid
    MF: C7H6N2
    MW: 118.139
    MP: n.a. oC

    Azaindoles (pyrrolopyridine) are indole bioisosteres for pharmaceutical optimization, for binding, solubility, and ADME properties.
    Product Name: Ethyl (3-R,S)-hydroxyl-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate
    Order number: RT-R07-142
    CAS: 95058-92-7
    Purity: >=95%
    Appearance: solid
    MF: C10H16F2O5
    MW: 254.23
    MP: n.a. oC

    This is a useful difluorosugar moiety for making antiviral nucleosides.